Endocrine Abstracts

Introduction: Primary squamous cell carcinoma (PSCC) of thyroid is a rare type of thyroid malignancies because thyroid gland lacks squamous epithelium. It is seen in <1% of all thyroid malignancies. During last 30 years only about 90 cases were published. PSCC is an aggressive tumour as well as rare.Case report: We present a 60-year-old female who had been followed up for multiple nodules in thyroid in our outpatient clinic for 2 years. Her serum fre...

Classic thyroid hormone resistance (THR) occurs per every 400 000 live birth. THR should be considered along with TSH-producing adenomas when normal or high levels of TSH not consistent with hyperthyroidism is present. A 45-year-old female patient who was operated three times for multinodulary goitre had been treated with L-thyroxine. Mamillary biopsy had performed after detection of mass localized in right breast by mammography performed during regular follow-u...

Introduction: Primary thyroid lymphomas are rare cancers and account 1–5% of all thyroid cancers and 3% of all extranodal non hodgkin lymphomas (NHLs). We aimed to present cases of thyroid lymphoma encountered in our clinic.Case 1: A 54-year-old female patient admitted with pain and swallow on the cervical region. In ultrasonographic (USG) thyroid examination, it was found that both thyroid lobes were very large with routh parenchyme consis...

Background: Although very rare, insulinomas are the most commonly occurring endocrine tumor of the pancreas. The aim of this study was to review the clinical presentation, diagnostic approach and management of patients with an insulinoma.Methods: 22 insulinoma patients, with an age range of 20–79, were included and evaluated according to their clinical presentation, blood biochemistry, imaging studies, operative management, pathological manifestatio...

Multiple myeloma is a neoplastic disorder arising from plasma cells in the bone marrow. Plasma cell tumors, plasmacytomas, are uncommon in the brain and occur usually in the leptomeninges with or without parencymal involvement. Extramedullary plasmacytomas are very rarely located in the sella and can be misdiagnosed as a nonfunctioning pituitary adenoma. We report an illustrative case with multiple myeloma who was diagnosed having sellar plasmacytoma resembling a nonfunctionin...

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

Benign symmetric lipomatosis (BSL) is a very rare disorder characterized by the growth of uncapsulated masses of adipose tissue, predominantly located in the neck and shoulders. Benign symmetric lipomatosis is usually described in adults between 30 and 60 years of age and is slightly more frequent in men with heavy alcohol consumption. A 70-year-old woman presented with a great growth of soft tissues in the cervico-occipital region who had never consumed any alcohol. Laborator...

A 50-year-old man admitted to our institution with labile hypertension. His blood pressure was 150/90 mmHg and the pulse rate was 96 beats per minute. He had hypertensive attacks every 2–3 days. His blood pressure was found 210/110 mmHg at hypertensive attact. He had palpable thyroid nodule. Ultrasonography of the thyroid gland showed a 2.6 cm sized, irregularly marginated, calcified thyroid nodule. His serum free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin ...

Although subclinical Cushing’s syndrome (SCS) is an important metabolic risk factor in patients with adrenal incidentaloma, the diagnostic criteria for SCS has not been established yet. The aim of this study was to evaluate the diagnostic measures of SCS and to investigate the availability of insülin hypoglycemia test (IHT) in the diagnosis of SCS. Twenty patients with adrenal incidentaloma CT characteristics highly suggestive of benign adrenal adenoma with no overt ...

The relationship between increased risk of cardiovascular disease (CVD) and atherosclerosis in subclinical hypothyroidism (sHT) have been demonstrated in several studies. This relation was attributed to dyslipidemia which is common in sHT. Apo A1, apo B100, Lp (a), hsC-reactive protein (hsCRP), fibrinogen and total homocysteinemia (tHcy) are the main non-traditional cardiovascular risk factors. In addition, paraoxon 1 (PON 1) activity is an enzyme responsible for the anti-oxid...